Repositorio Académico UPC

Genome-wide approaches including polygenic risk scores (PRSs) are now widely used in medical research; however, few studies have been conducted in low- and middle-income countries (LMICs), especially in South America. This study was designed to test the transferability of psychiatric PRSs to individuals with different ancestral and cultural backgrounds and to provide genome-wide association study (GWAS) results for psychiatric outcomes in this sample. The PrOMIS cohort (N = 3308) was recruited from prenatal care clinics at the Instituto Nacional Materno Perinatal (INMP) in Lima, Peru. Three major psychiatric outcomes (depression, PTSD, and suicidal ideation and/or self-harm) were scored by interviewers using valid Spanish questionnaires. Illumina Multi-Ethnic Global chip was used for genotyping. Standard procedures for PRSs and GWAS were used along with extra steps to rule out confounding due to ancestry. Depression PRSs significantly predicted depression, PTSD, and suicidal ideation/s...

The article presents a mapping of digital fabrication laboratories in South America from the architecture and urbanism field. First, it draws a brief context of implementation of facilities and growing of expertise highlighting economic, academic and cultural aspects. Second, it presents some data mapped from 31 laboratories of the region, as infrastructure, and correlations between uses and applications. Third, it organizes the mapped laboratories in two significant approaches for the region’s context: works focused on technological development and actions directed to the social and environmental development. Fourth, it infers some possible steps of the field in the region in the near future. Autor(es) :   Sperling, David M. ;   Herrera Polo, Pablo C. ;   Celani, Gabriela ;   Scheeren, Rodrigo Editorial :  Blucher Design Proceedings Revista:  Blucher Design Proceedings ISSN: 2318-6968 Fecha de publicación:  Noviembre 2015 URL :  http://hdl.handle...