Repositorio Académico UPC

El Consejo Superior de Investigaciones Científicas, CSIC publicó el Ranking web de Repositorios Institucionales - Julio 2015. En esta nueva edición, para el caso de Perú, el Repositorio Académico UPC  se ubicó en el 6to. puesto , ascendiendo dos posiciones en relación a la edición de Enero 2015. A nivel mundial se ubicó en el puesto 1121, ascendiendo 73 posiciones en relación a Enero 2015. Para Latino América, se ubicó en el puesto  102. Fuente: Webometrics URL: Texto completo Orden general Ordenado por el filtro "Size", 14vo puesto Ordenado por el filtro "Visibility", 6to. puesto Ordenado por el filtro "Rich Files" 5to. puesto Ordenado por el filtro "Scholar" 5to. puesto Ranking Mundial puesto 1121  Ranking Latinoamericano puesto 102

Gorham-Stout syndrome is an extremely rare pathology, of unknown etiology. It is characterized by proliferation of vascular channels that causes destruction and reabsorption of the bone matrix. We present a nine year-old male patient with an acute episode characterized by fever, chest pain, respiratory distress and dyspnea. The patient was submitted to computed tomography scan and a biopsy. The findings in the biopsy were multiple lytic lesions, osteolysis, and a mediastinal lymphangioma (lymphangiomatosis). The diagnosis was Gorham-Stout syndrome with atypical presentation Authors:  González Luna, Alejandro ;  Nuñez Pizarro, Jorge Luis ;  Rodríguez Echegaray, Clodo Iván Source:  Archivos argentinos de pediatría (Arch. argent. pediatr.) URL:  http://hdl.handle.net/10757/555429

Objective: To characterize two Achromobacter xylosoxidans recovered from 2 patients diagnosed with pertussis during a Bordetella pertussis surveillance program. Methods: Nasopharyngeal swabs from 2 children under 1 year of age with clinical suspicion of pertussis were analyzed by culture and PCR. Results: Two Achromobacter xylosoxidans A8, closely related to Bordetella spp. were recovered from 2 patients diagnosed of pertussis, both carrying the ptxA gene and IS418 the pertussis toxin encoding gene. Subsequently, antibiotic susceptibility was evaluated by disk-diffusion method and by PCR. Conclusions: Although more detailed studies are needed, the present data highlight the possibility that Achromobacter xylosoxidans, closely related Bordetella pertussis microorganisms and not covered under the vaccine umbrella, might also result in cases of whooping cough. Thereby further surveillance is necessary to determine the extension and relevance of their pathogenic role in order to ...

Although the National Committee of Medical Residency (CONAREME) has increased the number of nephrology residency positions in Peru, the increase has not been proportional to the number of applicants. This is worrisome in an environment lacking of nephrologists, like our country. The Peruvian Society of Nephrology (SPN) should take the measures to make this specialty more attractive to Peruvian physicians. Authors:  Herrera Añazco, Percy ;  Mezones Holguin, Edward ;  Hernandez, Adrian V. Source:  Jornal Brasileiro de Nefrologia (J. Bras. Nefrol) URL:  http://hdl.handle.net/10757/554221

Introducción y objetivos Los trastornos del sueño son una de las comorbilidades más comunes en pacientes en hemodiálisis. Los objetivos del estudio fueron determinar la prevalencia de mala calidad de sueño y establecer los potenciales factores asociados a ella. Materiales y métodos Estudio transversal analítico que enroló a pacientes con enfermedad renal crónica en hemodiálisis. La variable resultado fue calidad de sueño evaluada mediante la escala de Pittsburgh, mientras que las variables de exposición fueron el tiempo en hemodiálisis, la historia de diabetes mellitus tipo 2 y de hipertensión arterial, la presencia de sintomatología depresiva, la presencia de anemia y el compromiso urémico. Se usó el modelo de regresión de Poisson para verificar las asociaciones de interés, reportándose razones de prevalencia (RP) e intervalos de confianza al 95% (IC 95%). Resultados Fueron enrolados un total de 450 pacientes, de los cuales, 259 (57,5%) fueron varones, y con una edad entre 18...

Introduction Three cases of M. ozzardi infection from 2 suburban communities in Iquitos, Peru, led to a suspicion of local transmission. The objective of the study was to determine the prevalence of filariasis by M. ozzardi and its associated factors among these communities. Materials and methods A cross-sectional study was performed, as well as an epidemiological survey and a thick smear blood test. Larvae and mosquitoes were collected. The adjusted OR (aOR) using multiple logistic regression was calculated. Results A total of 433 participants were enrolled; 58% were women. The prevalence of M. ozzardi was 1.4% and the associated factors included being a fisherman (aOR: 8.7; 95%CI: 1.1–76.0) and being on the Alto Nanay river (aOR: 11.2; 95%CI: 1.2–112.5). No significant evidence of simulidos or culicoides was found. Conclusion The low prevalence of M. ozzardi found suggests a foreign infection, probably derived from the Alto Nanay river. Authors:  Arróspide, Nancy ;...

Hemorragic dengue fever is a prevalent infection in many countries around the world. Myocarditis is a severe manifestation of dengue virus infection. With prompt intervention and an early diagnosis, the outcome of this condition can be improve. We report a adult patient with complicated dengue, myocarditis, cardiac and respiratory insufficiency with acute renal injury. Authors:  Pereda, María Gracia ;  López, Marianelly ;  Mariluz, Melissa Source:  Revista Chilena de Infectología (Rev Chilena Infectol.) URL:  http://hdl.handle.net/10757/552889

Sr. Editor: En el 2008 se registró que la hipertensión es la causa del 45% de muertes por cardiopatías y del 51% de muertes por accidentes cardiovasculares en el mundo. Muchos factores pueden contribuir al aumento de las tasas de hipertensión, pero actualmente, el debate se ha centrado en el consumo de sal.2 La Organización Mundial de la Salud (OMS) ha recomendado la reducción del consumo de sal tanto en adultos a menos de 2 g de sodio por día, como en niños de 2 a 15 años, ajustándose de acuerdo a las necesidades de energía de los niños en comparación con las de los adultos.3 Autores: Trujillo Espino, Stefany; Paredes Aramburú, Jacqueline; Miranda Rodríguez, Camila; Bernabé Ortiz, Antonio Fuente:  Archivos argentinos de pediatría (Arch Argent Pediatr.) URL:  http://hdl.handle.net/10757/552698

Introducción: La labor asistencial puede condicionar pobre dedicación a actividades de investigación científica en médicos que realizan la especialización de nefrología. Objetivo: Describir las prácticas de investigación científica entre los médicos residentes en nefrología y especialistas recién egresados en Perú. Material y métodos: Se realizó un estudio descriptivo de corte transversal sobre la totalidad de médicos residentes de nefrología de los dos últimos años y especialistas egresados de los dos últimos años a nivel nacional, mediante un cuestionario autoaplicado. Resultados: Se obtuvieron 40 respuestas, de las cuales el 50% correspondían a residentes. El 67.5% de los encuestados nunca realizó investigación durante la residencia. Ningún encuestado que haya realizado algún trabajo de investigación lo publicó. Casi todos consideraron a su sede hospitalaria como deficiente en investigación. Conclusión: La investigación científica entre residentes de nefrología en Perú es deficiente...

Background Randomized controlled trials (RCTs) of endovascular therapy for acute ischemic stroke have had inconsistent results. We evaluated the efficacy and safety of endovascular therapy in published RCTs. Methods We performed a systematic review of RCTs of endovascular therapy with thrombolytic or mechanical reperfusion compared with interventions without endovascular therapy. Primary outcome was the frequency of good functional outcome (modified Rankin scale (mRS) of 0-2 at 90 days) and secondary outcomes were mortality at 90 days and symptomatic intracranial hemorrhage (sICH). Random-effects meta-analysis was performed and the Cochrane risk of bias assessment was used to evaluate quality of evidence. Results Ten studies involving 1,612 subjects were included. Endovascular therapy was not significantly associated with good functional outcome (Relative Risk [RR] =1.17; 95% CI, 0.97 to 1.42; p=0.10 and Absolute Risk Difference [ARD] =7%; 95%CI -0.1% to 14%; p=0.05); he...

Background: Antepartum depression is one of the leading causes of maternal morbidity and mortality in the prenatal period. There is accumulating evidence for the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of depression. The present study examines the extent to which maternal early pregnancy serum BDNF levels are associated with antepartum depression. Method: A total of 968 women were recruited and interviewed in early pregnancy. Antepartum depression prevalence and symptom severity were assessed using the Patient Health Questionnaire-9 (PHQ-9) scale. Maternal serum BDNF levels were measured using a competitive enzyme-linked immunosorbent assay (ELISA). Logistic regression procedures were performed to estimate odds ratios (OR) and 95% confidence intervals (95% CI) adjusted for confounders. Results: Maternal early pregnancy serum BDNF levels were significantly lower in women with antepartum depression compared to women without depression (mean ± standard devi...

En un informe emitido en marzo del 2013, la  Organización Mundial de Café (OIC)  señaló que el brote de  Roya Amarilla del Café  es una de las más graves plagas que afectan a esta planta en toda su historia de cultivo. Es así que cinco países centroamericanos declararon en estado de emergencia su actividad de  caficultura . Estos son  Guatemala, México, Costa Rica, Honduras y Panamá .  Pero todo esto ya es parte del pasado. En la actualidad, un equipo científico de la Universidad Nacional Mayor de San Marcos, ha encontrado la  posible cura  a esta epidemia que afecta gravemente a las naciones, incluido el Perú. Fuente: Texto completo

OBJECTIVE: Generalized anxiety disorder (GAD) during pregnancy is associated with several adverse maternal and perinatal outcomes. A reliable and valid screening tool for GAD should lead to earlier detection and treatment. Among pregnant Peruvian women, a brief screening tool, the GAD-7, has not been validated. This study aims to evaluate the reliability and validity of the GAD-7. METHODS: Of 2,978 women who attended their first perinatal care visit and had the GAD-7 screening, 946 had a Composite International Diagnostic Interview (CIDI). The Cronbach's alpha was calculated to examine the reliability. We assessed the criterion validity by calculating operating characteristics. The construct validity was evaluated using factor analysis and association with health status on the CIDI. The cross-cultural validity was explored using the Rasch Rating Scale Model (RSM). RESULTS: The reliability of the GAD-7 was good (Cronbach's alpha = 0.89). A cutoff score of 7 or higher, maxim...

Neuroendocrine tumors of the cervix are extremely rare. Women diagnosed with small cell neuroendocrine carcinoma of the cervix have a higher frequency of metastases in the lymph nodes, lymphovascular invasion, recurrence and worse prognosis compared to those with other types of cervical neoplasia. We report the case of a 58-year-old female, with a history of six years of postmenopausal irregular vaginal bleeding, in addition to symptoms related to chronic anemia. Gynecological examination showed a tumor of 4 cm that occupied the upper third of the vagina and protruded through the cervix initially diagnosed as an abortifacient myoma, and sent to histopathology study. 90% of the tumor was small cell neuroendocrine carcinoma grade III, and the remaining 10% was squamous cell carcinoma. The patient underwent into a radical hysterectomy plus bilateral salpingo-oophorectomy, and bilateral pelvic and para-aortic lymphadenectomy. Histopathologic examination of the surgical specimen found endom...

Objective: Identify the frequency of negative appendectomy (NA) and associated factors associated in a private hospital in Lima. Methods: Retrospective study of all appendectomies performed between 2012 and 2013 at a private hospital of Lima-Peru. We reviewed the medical records of patients who underwent appendectomy and had a medical report of emergency. We excluded the ones without pathology reports. Adjusted ORs were calculated with a logistic regression model to identify factors associated with AN. Results: Three hundred seventy-six appendectomies were performed for suspected appendicitis 55.9% in women). The average patient age was 33.4 ± 17.6 years. We identified 28 AN cases of 363 patients (7.7%). We found that pain in right flank (aOR: 5.4; 95%CI: 1.4-20.8), negative Mc Burney (aOR: 3.6; 95%CI: 1.3- 10.5), pain in hypogastrium (aOR: 3.1; 95%CI: 1.1-8.4) and no leucocitosis (aOR: 2.9; 95%CI: 1.2-6.7) were associated factors to AN. Gynecologic conditions (53.6%) and c...

Background Cardiovascular disease in the context of human immunodeficiency virus infection has become a major clinical concern in recent years. In the current report we assess hospitalizations due to cardiovascular disease in human immunodeficiency virus patients in a Social Security reference hospital in Peru. Methods A retrospective study was carried out between January 1996 and December 2012 in a General Hospital in Lima, Peru. Results We included 26 patients hospitalized due to cardiovascular disease. Mean age was 46.3 years (SD 12.5), predominantly male (57.7%). Ten patients (38.4%) were in Acquired Immunodeficiency Syndrome stages. Seventeen (65.4%) received high-active-antiretroviral therapy. Eleven (42.3%) had cardiac involvement and 15 (57.7%) had non-cardiac vascular involvement. The most frequent causes of cardiac involvement were pericardial effusion and myocardial infarction. On the other hand, deep vein thrombosis and stroke were the most frequent for non-cardiac...

A39-year-old woman from the south highland of Peru presented with abdominal distention, 10-kg weight gain, and intense stabbing pain in right upper quadrant of the abdomen. On physical examination, she had abdominal dullness and distention. She had a history of a liver cyst diagnosed by ultrasound 14 years ago. Three years ago a second ultrasound showed 3 cysts inside the first one. She did not receive any treatment before this hospitalization. The patient used to raise dogs and livestock (sheep and cattle) in her rural house when she was a child. The current ultrasound showed large cysts in liver and spleen that were confirmed by an abdominal computed tomography (CT) scan that revealed that both cysts contained hundreds of smaller cysts inside. Laboratory results showed a positive enzyme-linked immunosorbent assay (immunoglobulin G) for hydatid cyst. Laparotomy was performed, and the liver cyst was removed as well as the entire spleen. Authors:  Cayo Quiñe, Alexandra ;  ...

Sr. Director: Los schwannomas, también conocidos como neurinomas, neurilemomas o fibroblastomas perineurales, se originan a partir de las células de Schwann del tejido nervioso periférico1,2. Pertenecen a la familia de tumores mesenquimatosos, son solitarios, de crecimiento lento, típicamente encapsulados y habitualmente bien diferenciados2,3. Pueden originarse del plexo de Auerbach (en la capa muscular) o del plexo de Meissner (en la submucosa), siendo el último el de menor frecuencia2. Su tamano˜ es variable (0,5-11 cm de diámetro). La localización más frecuente corresponde a las regiones cefálica y cervical1---3; raramente se originan en el tracto gastrointestinal, pero de presentarse ahí, el segmento más afectado es el estómago2. Autores:  Pinedo Pichilingue, Aranza ;  Quijano Ono, Javier Fuente:  Gastroenterología y Hepatología (Gastroenterol Hepatol) URL:  http://hdl.handle.net/10757/527969

The primary intestinal follicular lymphoma is a rare disease described in the last classification of lymphomas from WHO. It is a localized disease with excellent prognosis. We describe in this article ,a 64 year-old Peruvian female with abdominal pain and delayed vomiting for the last two years, has undergone a partial intestinal resection due to bowel obstruction. There was a well-circumscribed annular tumor. A diagnosis of non-polypoid primary intestinal follicular lymphoma was made. We report the case and review the literature in this article. Authors:  Beltran, Brady ;  Carlos Alva, José ;  Morales, Domingo ;  Portanova, Michel Source:  Revista de Gastroenterología del Perú (Rev Gastroenterol Peru) URL:  http://hdl.handle.net/10757/348591

Sr. Editor. Hemos leído la respuesta de Mujica et al. a nuestro manuscrito sobre el requisito obligatorio del servicio social en salud (SERUMS) (1). Ellos basan su comentario sobre uno de los aspectos introductorios del artículo (la búsqueda de evidencias sobre el efecto de la intervención) y no sobre el fondo de nuestra propuesta, ya que mencionan que la “inefectividad de un programa social no lo hace necesariamente inconstitucional (i.e., falacia non sequitur)”. Este comentario nos llama la atención porque en ninguna parte del manuscrito hemos afirmado que la inconstitucionalidad se deba a la falta de evidencias de efectividad del programa, sino al requisito obligatorio del SERUMS para que los recursos humanos en salud (RHUS) puedan ingresar a programas de segunda especialización, ocupar cargos en entidades púbicas, recibir becas u otra ayuda equivalente para estudios o perfeccionamiento (2). Nosotros basamos nuestro análisis de inconstitucionalidad en que este requisito obligatorio ...

We report the case of a 10 year old girl, born and raised in the city of Iquitos in Peru who presented with headache, fever, chills, musculoskeletal pain, mild epigastric pain, epistaxis and hematemesis. On physical examination, the patient was afebrile and in good general condition. Serological tests confirmed infection of dengue and leptospirosis. The patient received intravenous hydration with sodium chloride 0.9% and penicillin G sodium, achieving a favorable clinical course such that she was discharged a few days after admission to the hospital. Although these diseases are common in the Peruvian Amazon, the simultaneous presence of both in the pediatric population is little documented; therefore, a good clinical history and laboratory tests are important for diagnosis and treatment. Authors:  Núñez Garbín, Alexandra ;  Espinoza Figueroa, Jossué ;  Sihuincha Maldonado, Moisés ;  Suárez Ognio, Luis Source:  Revista Peruana de Medicina Experimental y Sal...

Sr. Editor. El bullying es un problema de salud pública que incluye a tres actores: la víctima, el victimario/ agresor y el observador, y es un hecho que está cada vez más presente en nuestra sociedad, pues se discute sus implicancias en escenarios de salud, educación y hasta en la prensa. Sin embargo, la información científica disponible sobre la magnitud del bullying en el Perú (Tabla 1) muestra prevalencias bastante elevadas y hasta alarmantes, por lo que es válido preguntarse si es que el bullying en el Perú se está midiendo de manera correcta. Autores:  Cobián Lezama, Carla ;  Nizama-Vía, Ayar ;  Ramos Aliaga, David ;  Mayta Tristán, Percy Fuente:  Revista Peruana de Medicina Experimental y Salud Pública (Rev Peru Med Exp Salud Publica) URL:  http://hdl.handle.net/10757/348574

Sr. Editor: Hemos leído con interés el artículo «Calidad de vida en pacientes con cáncer de próstata, operados de prostatectomía radical laparoscópica», desarrollado por Sierra-Guerra et al., donde se describe el impacto del cáncer de próstata en la calidad de vida de los pacientes afectados1. Al respecto, existen varios instrumentos para evaluar este aspecto, siendo los más importantes el University of California-Los Angeles Prostate Cancer Index (UCLA-PCI), el Expanded Prostate Cancer Index (EPIC) y el Cuestionario Espanol ˜ de Calidad de Vida en Pacientes con Cáncer de Próstata (CAVIPRES). El UCLA-PCI fue el primer instrumento desarrollado para este fin, fue hecho en Estados Unidos y luego adaptado y validado al espanol ˜ en varios estudios latinamericanos2. El EPIC es una versión extendida del UCLA y, a diferencia de este, también puede ser utilizado en pacientes con estadios clínicos avanzados. Ambos son enfermedad-específicos y, por lo tanto, más sensibles que los generales3. Aut...

Introduction: Living at high altitudes requires the inhabitants to adapt biologically and socially to the environment. The objective of this study was to determine the difference in physical performance (PP) in rural populations at sea level and at high altitude. Material and methods: A cross-sectional study was conducted in rural communities in Ancash, Peru, located at 3.345 meters above sea level (m.a.s.l.) and also in communities located in coastal areas at 6 m.a.s.l. PP was measured by the Short Physical Performance Battery (SPPB) and other associated factors. Adjusted prevalence ratios (aPR) were calculated. Results: A total of 130 older adults were assessed in the high altitude communities and 129 on the coast. The median age was 71.4 years, and 55.6 % were female. Low physical performance (SPPB ≤ 6) was 10.0 % at high altitude and 19.4 % on the coast (p <0.05). Factors associated with low physical performance were residing at the coast (aPR: 2.10, 95 % CI 1.02 to 4.3...